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Tacrolimus

Chemical Structure : Tacrolimus

CAS No.: 104987-11-3

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Tacrolimus (FK506, Fujimycin, FR900506)

Catalog No.: PC-22184Not For Human Use, Lab Use Only.

Tacrolimus (FK506) is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex, inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription, shows immunosuppressive properties.

Packing Price Stock Quantity
5 mg (Free Sample) $18 In stock
50 mg $128 In stock
100 mg $198 In stock
250 mg $288 In stock
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Biological Activity

Tacrolimus (FK506) is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex, inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription, shows immunosuppressive properties.

Physicochemical Properties

M.Wt 804.03
Formula C44H69NO12
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

References

1. Tocci MJ, et al. J Immunol. 1989 Jul 15;143(2):718-26.

2. Standaert RF, et al. Nature. 1990 Aug 16;346(6285):671-4.

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