Catalog No.: PC-21041Not For Human Use, Lab Use Only.
Tamibarotene (Am-80, SY-1425) is a potent and selective retinoic acid receptor α (RARα) agonist with high selectivity over RARγ, exhibits anti-angiogenic activity.
Tamibarotene (Am-80, SY-1425) is a potent and selective retinoic acid receptor α (RARα) agonist with high selectivity over RARγ, exhibits anti-angiogenic activity. Tamibarotene (Am-80, SY-1425) is a potent inhibitor of proliferation in the RARA-high AML cell lines, with EC50s that ranged from 0.14 nM-0.9 nM, with no effect on the RARA-low cell lines up to the highest concentration tested (2 μM). Tamibarotene (Am-80, SY-1425) induces maturation in RARA-high AML, exerts transcriptional and chromatin alterations in RARA-high cell lines.
