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Chemical Structure : Tamibarotene
CAS No.: 94497-51-5
Catalog No.: PC-21041Not For Human Use, Lab Use Only.
Tamibarotene (Am-80, SY-1425) is a potent and selective retinoic acid receptor α (RARα) agonist with high selectivity over RARγ, exhibits anti-angiogenic activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Tamibarotene (Am-80, SY-1425) is a potent and selective retinoic acid receptor α (RARα) agonist with high selectivity over RARγ, exhibits anti-angiogenic activity.
Tamibarotene (Am-80, SY-1425) is a potent inhibitor of proliferation in the RARA-high AML cell lines, with EC50s that ranged from 0.14 nM-0.9 nM, with no effect on the RARA-low cell lines up to the highest concentration tested (2 μM).
Tamibarotene (Am-80, SY-1425) induces maturation in RARA-high AML, exerts transcriptional and chromatin alterations in RARA-high cell lines.
| M.Wt | 351.45 | |
| Formula | C22H25NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid |
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1. T Oikawa, et al. Eur J Pharmacol. 1993 Nov 2;249(1):113-6.
2. Nakazato T, et al. Cancer Sci. 2008 Nov;99(11):2286-94.
3. de Botton S, et al. Blood Adv. 2023 May 9;7(9):1858-1870.
4. McKeown MR, et al. Cancer Discov. 2017 Oct;7(10):1136-1153.
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