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Tat-NR2B9c

Chemical Structure : Tat-NR2B9c

CAS No.: 500992-11-0

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Tat-NR2B9c (NA-1)

Catalog No.: PC-47499Not For Human Use, Lab Use Only.

Tat-NR2B9c (NA-1) is a neuroprotective agent, exhibits high-affinity binding to the second PDZ domain of PSD-95, inhibits NR2A-NR2C/PSD-95 interactions (IC50=1-10 uM) and nNOS/PSD-95 interaction (IC50=200 nM).

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5 mg $138 In stock
10 mg $218 In stock
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50 mg $558 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tat-NR2B9c (NA-1) is a neuroprotective agent, exhibits high-affinity binding to the second PDZ domain of PSD-95, inhibits NR2A-NR2C/PSD-95 interactions (IC50=1-10 uM) and nNOS/PSD-95 interaction (IC50=200 nM).

Physicochemical Properties

M.Wt 2518.88
Formula C105H188N42O30
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: 30 mM (75.6 mg/mL)
Chemical Name/SMILES

L-Valine, L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-leucyl-L-seryl-L-seryl-L-isoleucyl-L-α-glutamyl-L-seryl-L-α-aspartyl-

References

1. Cui H, et al. J Neurosci. 2007 Sep 12;27(37):9901-15.

2. Sun HS, et al. Stroke. 2008 Sep;39(9):2544-53.

3. Soriano FX, et al. J Neurosci. 2008 Oct 15;28(42):10696-710.

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