Tax-1-hDLG1 inhibitor 3

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Chemical Structure : Tax-1-hDLG1 inhibitor 3

Catalog No.: PC-20988Not For Human Use, Lab Use Only.

Tax-1-hDLG1 inhibitor 3 is a small molecule inhibitor of Tax-1-hDLG1 interaction with EC50 of 11.5 uM, blocks HTLV-1 cell to cell transmission and viral replication.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Tax-1-hDLG1 inhibitor 3 is a small molecule inhibitor of Tax-1-hDLG1 interaction with EC50 of 11.5 uM, blocks HTLV-1 cell to cell transmission and viral replication.
Tax-1-hDLG1 inhibitor 3 is a competitive inhibitor of the Tax-1-hDLG1 PDZ interaction, binds to both hDLG1 PDZ1 and PDZ2 domains, with affinity constants (KD) in the 14-21 uM.
Tax-1-hDLG1 inhibitor 3 (50 uM, 48 h) inhibits HTLV-1 viral replication in MT2 and C91 cells, decreases the expression of the structural protein Gag for both cell lines, does not show anti-viral effect against HIV-1.

Physicochemical Properties

M.Wt	430.39
Formula	C25H15FO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	FC1=CC(C(C(C2=O)=C(O)C3=C(O2)C=CC=C3)C(C4=O)=C(O)C5=C(O4)C=CC=C5)=CC=C1

References

1. Maseko SB, et al. Antiviral Res. 2023 Jul 20:105675.

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