Tecalcet |CAS:148717-54-8 Probechem Biochemicals

Chemical Structure : Tecalcet

Tecalcet (R-568;NPS R-568;KRN-568;NPS-568)

Catalog No.: PC-62909Not For Human Use, Lab Use Only.

Tecalcet (R-568, NPS R-568, KRN-568, NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.

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Biological Activity

Tecalcet (R-568, NPS R-568, KRN-568, NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
Tecalcet (R-568) potentiates the effects of extracellular Ca2+ on [Ca2+]i and PTH secretion (IC50=27 nM in bovine parathyroid cells) without effect in the absence of extracellular Ca2+, does not affect responses elicited by the homologous mGluRs.

Physicochemical Properties

M.Wt	303.83
Formula	C18H22ClNO
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine

References

1. Wada M, et al. J Clin Invest. 1997 Dec 15;100(12):2977-83., et al.

2. Nemeth EF, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4040-5.

3. Wada M, et al. Kidney Int. 2000 Jan;57(1):50-8.

4. Hammerland LG, et al. Mol Pharmacol. 1998 Jun;53(6):1083-8.

Tecalcet (R-568;NPS R-568;KRN-568;NPS-568)

Biological Activity

Physicochemical Properties

References

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