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Chemical Structure : Tecalcet
Catalog No.: PC-62909Not For Human Use, Lab Use Only.
Tecalcet (R-568, NPS R-568, KRN-568, NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
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Tecalcet (R-568, NPS R-568, KRN-568, NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
Tecalcet (R-568) potentiates the effects of extracellular Ca2+ on [Ca2+]i and PTH secretion (IC50=27 nM in bovine parathyroid cells) without effect in the absence of extracellular Ca2+, does not affect responses elicited by the homologous mGluRs.
| M.Wt | 303.83 | |
| Formula | C18H22ClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wada M, et al. J Clin Invest. 1997 Dec 15;100(12):2977-83., et al.
2. Nemeth EF, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4040-5.
3. Wada M, et al. Kidney Int. 2000 Jan;57(1):50-8.
4. Hammerland LG, et al. Mol Pharmacol. 1998 Jun;53(6):1083-8.
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