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Chemical Structure : Temsirolimus
CAS No.: 162635-04-3
Catalog No.: PC-60132Not For Human Use, Lab Use Only.
Temsirolimus (CCI779, Torisel) is a rapamycin ester and mTOR inhibitor with biochemical IC50 of 1.74 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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Temsirolimus (CCI779, Torisel) is a rapamycin ester and mTOR inhibitor with biochemical IC50 of 1.74 uM.
Temsirolimus (CCI779, Torisel) reduces global protein synthesis and disassembly of polyribosomes, increases the phosphorylation of eEF2 and the translation initiation factor eIF2 alph.
Temsirolimus (CCI779, Torisel) inhibits mTOR signaling through an FKBP12-independent mechanism in cancer cells.
Temsirolimus (CCI779, Torisel) reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice, with no effect on Akt.
| M.Wt | 1030.29 | |
| Formula | C56H87NO16 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
40-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]-rapamycin |
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1. Geoerger B, et al. Cancer Res. 2001 Feb 15;61(4):1527-32.
2. Dudkin L, et al. Clin Cancer Res. 2001 Jun;7(6):1758-64.
3. Podsypanina K, et al. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10320-5.
4. Shor B, et al. Cancer Res. 2008 Apr 15;68(8):2934-43.
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