Temsirolimus |CAS:162635-04-3 Probechem Biochemicals

Chemical Structure : Temsirolimus

CAS No.: 162635-04-3

Temsirolimus (CCI-779;CCI779;Torisel)

Catalog No.: PC-60132Not For Human Use, Lab Use Only.

Temsirolimus (CCI779, Torisel) is a rapamycin ester and mTOR inhibitor with biochemical IC50 of 1.74 uM.

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10 mg	$118	In stock
25 mg	$188	In stock
50 mg	$298	In stock
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Biological Activity

Temsirolimus (CCI779, Torisel) is a rapamycin ester and mTOR inhibitor with biochemical IC50 of 1.74 uM.
Temsirolimus (CCI779, Torisel) reduces global protein synthesis and disassembly of polyribosomes, increases the phosphorylation of eEF2 and the translation initiation factor eIF2 alph.
Temsirolimus (CCI779, Torisel) inhibits mTOR signaling through an FKBP12-independent mechanism in cancer cells.
Temsirolimus (CCI779, Torisel) reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice, with no effect on Akt.

Physicochemical Properties

M.Wt	1030.29
Formula	C56H87NO16
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	40-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]-rapamycin

References

1. Geoerger B, et al. Cancer Res. 2001 Feb 15;61(4):1527-32.

2. Dudkin L, et al. Clin Cancer Res. 2001 Jun;7(6):1758-64.

3. Podsypanina K, et al. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10320-5.

4. Shor B, et al. Cancer Res. 2008 Apr 15;68(8):2934-43.

Temsirolimus (CCI-779;CCI779;Torisel)

Biological Activity

Physicochemical Properties

References

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