Them1 inhibitor Compound U1

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Chemical Structure : Them1 inhibitor Compound U1

Catalog No.: PC-25885Not For Human Use, Lab Use Only.

Them1 inhibitor Compound U1 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively inhibits Them1 by binding the START domain (Kd=5.97 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Them1 inhibitor Compound U1 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively inhibits Them1 by binding the START domain (Kd=5.97 uM).
U1 binds to and destabilizes the Them1 START domain.
U1 (10 uM) increase fatty acid oxidation rates in cultured primary brown adipocytes.
U1 (33 uM) increase fatty acid oxidation rates and suppress glucose production in cultured primary hepatocytes.

Physicochemical Properties

M.Wt	383.51
Formula	C21H25N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-((2-methyl-1H-indol-3-yl)(thiophen-2-yl)methyl)piperazine-1-carboxylate

References

1. Krumm CS, et al. Mol Metab. 2023 Dec;78:101832.

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