Catalog No.: PC-43111Not For Human Use, Lab Use Only.
Thiamet-G is a potent, selective O-GlcNAcase inhibitor with Ki of 21 nM for human O-GlcNAcase, blocks phosphorylation of tau both in vitro and in vivo.
Thiamet-G is a potent, selective O-GlcNAcase inhibitor with Ki of 21 nM for human O-GlcNAcase, blocks phosphorylation of tau both in vitro and in vivo.
Thiamet-G decreases phosphorylation of tau in PC-12 cells at pathologically relevant sites including Thr231 and Ser396.
Thiamet-G also efficiently reduces phosphorylation of tau at Thr231, Ser396 and Ser422 in both rat cortex and hippocampus, which reveals the rapid and dynamic relationship between O-GlcNAc and phosphorylation of tau in vivo.
Thiamet-G stimulates chondrogenic differentiation both in vitro and in vivo.
