Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Thiamet G
CAS No.: 1009816-48-1
Catalog No.: PC-43111Not For Human Use, Lab Use Only.
Thiamet-G is a potent, selective O-GlcNAcase inhibitor with Ki of 21 nM for human O-GlcNAcase, blocks phosphorylation of tau both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $548 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Thiamet-G is a potent, selective O-GlcNAcase inhibitor with Ki of 21 nM for human O-GlcNAcase, blocks phosphorylation of tau both in vitro and in vivo.
Thiamet-G decreases phosphorylation of tau in PC-12 cells at pathologically relevant sites including Thr231 and Ser396.
Thiamet-G also efficiently reduces phosphorylation of tau at Thr231, Ser396 and Ser422 in both rat cortex and hippocampus, which reveals the rapid and dynamic relationship between O-GlcNAc and phosphorylation of tau in vivo.
Thiamet-G stimulates chondrogenic differentiation both in vitro and in vivo.
| M.Wt | 248.2993 | |
| Formula | C9H16N2O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 45 mg/mL |
|
| Chemical Name/SMILES |
5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)- |
|
1. Yuzwa SA, et al. Nat Chem Biol. 2008 Aug;4(8):483-90.
2. Goldberg H, et al. Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E713-26.
3. Yuzwa SA, et al. Nat Chem Biol. 2012 Feb 26;8(4):393-9.
4. Andrés-Bergós J, et al. J Biol Chem. 2012 Sep 28;287(40):33615-28.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
