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Thiazolidine-2-carboxylate

Chemical Structure : Thiazolidine-2-carboxylate

CAS No.: 16310-13-7

Thiazolidine-2-carboxylate (T2C)

Catalog No.: PC-27845Not For Human Use, Lab Use Only.

Thiazolidine-2-carboxylate (T2C) is a covalent, irreversible inhibitor of proline dehydrogenase (PRODH), covalently binds to the N5 of the FAD in the PRODH domain. also inhibits pyrroline-5-carboxylate reductase 1 (PYCR1).

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Biological Activity

Thiazolidine-2-carboxylate (T2C) is a covalent, irreversible inhibitor of proline dehydrogenase (PRODH), covalently binds to the N5 of the FAD in the PRODH domain. also inhibits pyrroline-5-carboxylate reductase 1 (PYCR1).

Physicochemical Properties

M.Wt 133.17
Formula C4H7NO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

thiazolidine-2-carboxylic acid

References

1. Campbell AC, et al. ACS Chem Biol. 2020 Apr 17;15(4):936-944.

2. Scott GK, et al. Amino Acids. 2021 Dec;53(12):1927-1939.

3. Christensen EM, et al. J Biol Chem. 2020 Dec 25;295(52):18316-18327.

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