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Ticagrelor

Chemical Structure : Ticagrelor

CAS No.: 274693-27-5

Ticagrelor (AR-C 126532XX, AZD6140, AZD-6140)

Catalog No.: PC-42218Not For Human Use, Lab Use Only.

Ticagrelor (AZD6140) is a potent, selective, reversible and oral P2Y12 receptor antagonist with pKi of 8.7.

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Biological Activity

Ticagrelor (AZD6140) is a potent, selective, reversible and oral P2Y12 receptor antagonist with pKi of 8.7.
Ticagrelor (AZD6140) effectively inhibits platelet aggregation without significant increases in bleeding time in vivo.
Ticagrelor (AZD6140) is used for the prevention of thrombotic events (for example stroke or heart attack) in people with acute coronary syndrome or myocardial infarction with ST elevation.

Physicochemical Properties

M.Wt 522.5681
Formula C23H28F2N6O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2-Cyclopentanediol, 3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-

References

1. VAN Giezen JJ, et al. J Thromb Haemost. 2009 Sep;7(9):1556-65.

2. Husted S, et al. Eur Heart J. 2006 May;27(9):1038-47.

3. Springthorpe B, et al. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8.

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