Tie2 inhibitor compound 5 | Tie2 inhibitor

Chemical Structure : Tie2 inhibitor compound 5

CAS No.: 948557-43-5

Tie2 inhibitor compound 5 (Tie2-IN-1)

Catalog No.: PC-24617Not For Human Use, Lab Use Only.

Tie2 inhibitor compound 5 (Tie2-IN-1) is a potent, selective Tie2 kinase inhibitor with IC50 of 250 nM, >200-fold selective over p38.

Packing	Price	Stock
2 mg	$78	In stock
5 mg	$118	In stock
10 mg	$188	In stock
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Biological Activity

Tie2 inhibitor compound 5 (Tie2-IN-1) is a potent, selective Tie2 kinase inhibitor with IC50 of 250 nM, >200-fold selective over p38.
Tie2 inhibitor compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.

Physicochemical Properties

M.Wt	439.53
Formula	C26H21N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(6-Methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine

References

1. Marcus Semones, et al. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4756-60.

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Tie2 inhibitor compound 5 (Tie2-IN-1)

Biological Activity

Physicochemical Properties

References

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