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Tivozanib

Chemical Structure : Tivozanib

CAS No.: 475108-18-0

Tivozanib (AV-951, AV951, KRN951)

Catalog No.: PC-42759Not For Human Use, Lab Use Only.

Tivozanib (AV951) is a highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tivozanib (AV951) is a highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3.
Tivozanib (AV951) also inhibits EphB2, PDGFR-α, PDGFR-β, c-Kit, and Tie2 (IC50=20-80 nM).
Tivozanib (AV951) inhibits VEGF-induced VEGFR-2 phosphorylation in endothelial cells (IC50=0.16 nM).
Tivozanib (AV951) is p.o. active.

Physicochemical Properties

M.Wt 454.8631
Formula C22H19ClN4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-

References

1. Nakamura K, et al. Cancer Res. 2006 Sep 15;66(18):9134-42.

2. Eskens FA, et al. Clin Cancer Res. 2011 Nov 15;17(22):7156-63.

3. Momeny M, et al. Sci Rep. 2017 Apr 6;7:45954.

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