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Tonapofylline

Chemical Structure : Tonapofylline

CAS No.: 340021-17-2

Tonapofylline (BG 9928;BG9928)

Catalog No.: PC-60741Not For Human Use, Lab Use Only.

Tonapofylline (BG9928) is a potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tonapofylline (BG9928) is a potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM.
Tonapofylline (BG9928) displays 915-foldselectivity over A2A receptor, 12-fold over A2B receptor.
Tonapofylline (BG9928) increases sodium excretion and cause natriuresis without causing kaliuresis or reducing renal function.

Physicochemical Properties

M.Wt 416.522
Formula C22H32N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3-dipropyl-8-[1-(4-propionate)-bicyclo-[2,2,2]octyl]xanthine

References

1. Auchampach JA, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):846-56.

2. Kiesman WF, et al. J Med Chem. 2006 Nov 30;49(24):7119-31.

3. Greenberg B, et al. J Am Coll Cardiol. 2007 Aug 14;50(7):600-6.

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