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Chemical Structure : Tpl2-1
CAS No.: 871307-18-5
Catalog No.: PC-70030Not For Human Use, Lab Use Only.
Tpl2-1 is a potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase (Cot/MAP3K8) with IC50 of 50 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $158 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote |
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Tpl2-1 is a potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase (Cot/MAP3K8) with IC50 of 50 nM.
Tpl2-1 dispalys significant selectivity over other related kinases (IC50= 5, >40, 110, 180, >400 and >400 uM for EGFR, MEK, MK2, p38, Src, and PKC, respectively).
Tpl2-1 inhibits LPS-induced TNF-α production both from primary human monocytes and in whole blood with IC50 of 0.7 and 8.5 uM, respectively;
| M.Wt | 404.83 | |
| Formula | C21H14ClFN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((3-chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile |
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1. Gavrin LK, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92.
2. Lee WJ, et al. Neoplasia. 2013 Sep;15(9):1036-48.
3. Lee HW, et al. Mol Cancer Res. 2013 Nov;11(11):1375-86.
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