A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM; exhibits no inhibition on the kinase activities of c-Raf, B-Raf, ERK1/2.
Skin Cancer
Approved
Physicochemical Properties
M.Wt
693.5283
Formula
C28H29FIN5O5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 69 mg/mL (Need ultrasonic)
Chemical Name/SMILES
N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1)
References
1. Gilmartin AG, et al. Clin Cancer Res. 2011 Mar 1;17(5):989-1000.
2. Flaherty KT, et al. N Engl J Med. 2012 Nov 1;367(18):1694-703.
3. Yamaguchi T, et al. Int J Oncol, 2011, 39(1), 23-31.
