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Chemical Structure : Trametinib DMSO solvate
CAS No.: 1187431-43-1
Catalog No.: PC-42775Not For Human Use, Lab Use Only.
A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $64 | In stock | |
| 100 mg | $95.2 | In stock |
Bulk size, bulk discount!
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A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM; exhibits no inhibition on the kinase activities of c-Raf, B-Raf, ERK1/2.
Skin Cancer
Approved
| M.Wt | 693.5283 | |
| Formula | C28H29FIN5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 69 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1) |
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1. Gilmartin AG, et al. Clin Cancer Res. 2011 Mar 1;17(5):989-1000.
2. Flaherty KT, et al. N Engl J Med. 2012 Nov 1;367(18):1694-703.
3. Yamaguchi T, et al. Int J Oncol, 2011, 39(1), 23-31.
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