Catalog No.: PC-70135Not For Human Use, Lab Use Only.
Tranilast (MK-341) is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.
Tranilast (MK-341) is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.
Tranilast (MK-341) is an inhibitor of calcium-permeable TRPV2 channel, inhibits insulin increased calcium entry in beta-cells.
Tranilast inhibits endotoxin-induced PGE2 (IC50=1-20 uM), thromboxane B2 (IC50= 10-50 uM), TGF-β1 (IC50=100-200 uM), and IL-8 (IC50=100 uM) formation, but has no effect on TNF-α.
Tranilast also inhibits VEGF-induced angiogenetic activities.
Tranilast also is an inhibitor of the transcription factor Forkhead box O-1 (FoxO-1).
