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Traxoprodil

Chemical Structure : Traxoprodil

CAS No.: 134234-12-1

Traxoprodil (CP-101606;CP101606)

Catalog No.: PC-70017Not For Human Use, Lab Use Only.

A potent and NR2B-selective NMDA receptor antagonist.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent and NR2B-selective NMDA receptor antagonist; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM); shows neuroprotective, analgesic, and anti-Parkinsonian effects in animal studies.

Parkinson's Disease

Phase 2 Discontinued

Physicochemical Properties

M.Wt 327.424
Formula C20H25NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol

References

1. Brimecombe JC, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):11019-24.

2. Chenard BL, et al. J Med Chem. 1995 Aug 4;38(16):3138-45.

3. Steece-Collier K, et al. Exp Neurol. 2000 May;163(1):239-43.

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