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Triacsin C

Chemical Structure : Triacsin C

CAS No.: 76896-80-5

Triacsin C (WS 1228A, FR 900190)

Catalog No.: PC-22161Not For Human Use, Lab Use Only.

Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD).
Triacsin C has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.
Triacsin C also act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.
Triacsin C inhibits pancreatic β-cell function by suppressing the mobilization of intracellular calcium.

Physicochemical Properties

M.Wt 207.28
Formula C11H17N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N'-((1E,2E,4E,7E)-undeca-2,4,7-trien-1-ylidene)nitrous hydrazide

References

1. Kim Y, et al. Eur J Med Chem. 2012 Apr;50:311-8.

2. Dechandt CRP, et al. J Bioenerg Biomembr. 2017 Oct;49(5):399-411.

3. Matsuda D, et al. J Antibiot (Tokyo). 2008 May;61(5):318-21.

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