Chemical Structure : Triacsin C
CAS No.:
76896-80-5
Triacsin C
(WS 1228A, FR 900190)
Catalog No.: PC-22161Not For Human Use, Lab Use Only.
Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD).
Triacsin C has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.
Triacsin C also act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.
Triacsin C inhibits pancreatic β-cell function by suppressing the mobilization of intracellular calcium.
Physicochemical Properties
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M.Wt
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207.28
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Formula
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C11H17N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N'-((1E,2E,4E,7E)-undeca-2,4,7-trien-1-ylidene)nitrous hydrazide
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References
1. Kim Y, et al. Eur J Med Chem. 2012 Apr;50:311-8.
2. Dechandt CRP, et al. J Bioenerg Biomembr. 2017 Oct;49(5):399-411.
3. Matsuda D, et al. J Antibiot (Tokyo). 2008 May;61(5):318-21.
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