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Triciribine

Chemical Structure : Triciribine

CAS No.: 35943-35-2

Triciribine (API-2, NSC 154020, TCN)

Catalog No.: PC-23340Not For Human Use, Lab Use Only.

Triciribine is a purine analog and DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively, selectively inhibits the phosphorylation and activation of all three Akt isoforms.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $198 In stock
50 mg $298 In stock
100 mg $458 In stock

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Triciribine is a purine analog and DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively, selectively inhibits the phosphorylation and activation of all three Akt isoforms.

Physicochemical Properties

M.Wt 320.31
Formula C13H16N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3R,4S,5R)-2-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

References

1. Dieterle A, et al. Int J Cancer. 2009 Aug 15;125(4):932-41.

2. Kucera LS, et al. AIDS Res Hum Retroviruses. 1993 Apr;9(4):307-14.

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