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Chemical Structure : Triptonide
CAS No.: 38647-11-9
Catalog No.: PC-45815Not For Human Use, Lab Use Only.
Triptonide (NSC 165677, PG 492) is a key bioactive small molecule identified in Tripterygium wilfordii Hook F., has a broad spectrum of biological functions, inhibits canonical Wnt/β-catenin signaling by targeting β-catenin.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
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Triptonide (NSC 165677, PG 492) is a key bioactive small molecule identified in Tripterygium wilfordii Hook F., has a broad spectrum of biological functions, inhibits canonical Wnt/β-catenin signaling by targeting β-catenin.
Triptonide effectively inhibits canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin.
Triptonide upregulates the expression of IL-37.
Triptonide potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC50 of 5.7 nM and 4.8 nM, respectively.
| M.Wt | 358.3851 | |
| Formula | C20H22O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione, 3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)- |
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1. Chinison J, et al. Sci Rep. 2016 Sep 6;6:32779.
2. He L, et al. Cell Mol Immunol. 2015 Jul;12(4):515-8.
3. Yang P, et al. Toxicol Lett. 2017 Jun 27;278:9-17.
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