Triptonide |CAS:38647-11-9 Probechem Biochemicals

Chemical Structure : Triptonide

CAS No.: 38647-11-9

Triptonide (NSC 165677;PG 492)

Catalog No.: PC-45815Not For Human Use, Lab Use Only.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$238	In stock
50 mg	$388	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Triptonide (NSC 165677, PG 492) is a key bioactive small molecule identified in Tripterygium wilfordii Hook F., has a broad spectrum of biological functions, inhibits canonical Wnt/β-catenin signaling by targeting β-catenin.
Triptonide effectively inhibits canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin.
Triptonide upregulates the expression of IL-37.
Triptonide potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC50 of 5.7 nM and 4.8 nM, respectively.

Physicochemical Properties

M.Wt	358.3851
Formula	C20H22O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione, 3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-

References

1. Chinison J, et al. Sci Rep. 2016 Sep 6;6:32779.

2. He L, et al. Cell Mol Immunol. 2015 Jul;12(4):515-8.

3. Yang P, et al. Toxicol Lett. 2017 Jun 27;278:9-17.

Triptonide (NSC 165677;PG 492)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.