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Tunicamycin

Chemical Structure : Tunicamycin

CAS No.: 11089-65-9

Tunicamycin

Catalog No.: PC-21959Not For Human Use, Lab Use Only.

Tunicamycin is a homologous nucleoside antibiotic and GlcNAc phosphotransferase (GPT) inhibitor, inhibits N-glycosylation and induces ER-stress, inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.

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Biological Activity

Tunicamycin is a homologous nucleoside antibiotic and GlcNAc phosphotransferase (GPT) inhibitor, inhibits N-glycosylation and induces ER-stress, inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.

Physicochemical Properties

M.Wt 718.71
Formula C30H46N4O16
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-N-((2S,3R,4R,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(2-((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-hydroxyethyl)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)-5-methylhex-2-enamide

References

1. Nonarath HJT, et al. J Antibiot (Tokyo). 2024 Jan 18. doi: 10.1038/s41429-023-00694-z.

2. Hsu JL, et al. Naunyn Schmiedebergs Arch Pharmacol. 2009 Nov;380(5):373-82.

3. Hou H, et al. Mol Cancer Ther. 2013 Dec;12(12):2874-84. 

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