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Chemical Structure : Tyk2-IN-30
Catalog No.: PC-63072Not For Human Use, Lab Use Only.
TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3).
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TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3).
TYK2-IN-30 potently inhibits IL-23 pathway in cells with EC50 of 66 nM, and has good pharmacokinetic properties.
TYK2-IN-30 demonstrates dose-dependent reduction of IL-17 production in a PK/PD model as well as in an imiquimod-induced psoriasis model.
| M.Wt | 396.235 | |
| Formula | C18H11Cl2N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liang J, et al. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4370-4376.
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