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Tyk2-IN-30

Chemical Structure : Tyk2-IN-30

CAS No.: 1334407-95-2

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Tyk2-IN-30

Catalog No.: PC-63072Not For Human Use, Lab Use Only.

TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3).
    TYK2-IN-30 potently inhibits IL-23 pathway in cells with EC50 of 66 nM, and has good pharmacokinetic properties.
    TYK2-IN-30 demonstrates dose-dependent reduction of IL-17 production in a PK/PD model as well as in an imiquimod-induced psoriasis model.

    Physicochemical Properties

    M.Wt 396.235
    Formula C18H11Cl2N7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,5-dichloro-4-(4-((6-methylpyrimidin-4-yl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)benzonitrile

    References

    1. Liang J, et al. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4370-4376.

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