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U73343

Chemical Structure : U73343

CAS No.: 142878-12-4

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U73343 (U-73343)

Catalog No.: PC-27057Not For Human Use, Lab Use Only.

U-73343 (U73343) an inactive analog of phospholipase C (PLC) inhibitor U73122, also is a potent enhancer of oligodendrocyte formation that induces 8,9-unsaturated sterol accumulation by inhibition of cholesterol biosynthesis enzyme sterol 14-reductase, also inhibits cholesterol 25-hydroxylase (CH25H).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

U-73343 (U73343) an inactive analog of phospholipase C (PLC) inhibitor U73122, also is a potent enhancer of oligodendrocyte formation that induces 8,9-unsaturated sterol accumulation by inhibition of cholesterol biosynthesis enzyme sterol 14-reductase, also inhibits cholesterol 25-hydroxylase (CH25H).

Physicochemical Properties

M.Wt 466.67
Formula C29H42N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(6-(((8R,9S,13S,14S,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)amino)hexyl)pyrrolidine-2,5-dione

References

1. Sax JL, et al. ACS Chem Biol. 2021 Jul 16;16(7):1288-1297.

2. Rahman A, et al. ACS Chem Biol. 2026 Jun 12. doi: 10.1021/acschembio.6c00385.

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