UAMC-1110 (SP-13786) | FAP inhibitor | Probechem Biochemicals

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Chemical Structure : UAMC-1110

CAS No.: 1448440-52-5

UAMC-1110 (UAMC1110, SP-13786, SP13786)

Catalog No.: PC-36075Not For Human Use, Lab Use Only.

UAMC-1110 (SP-13786) is a potent, selective small molecule inhibitor of fibroblast activation protein (FAP) with IC50 of 3.2 nM.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$348	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UAMC-1110 (SP-13786) is a potent, selective small molecule inhibitor of fibroblast activation protein (FAP) with IC50 of 3.2 nM.
UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with IC50 of 1.8 uM.

Physicochemical Properties

M.Wt	344.322
Formula	C17H14F2N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide

References

1. Gunderson AJ, et al. PLoS One. 2019 Feb 6;14(2):e0211117.

2. Jansen K, et al. ACS Med Chem Lett. 2013 Mar 18;4(5):491-6.

3. Jansen K, et al. J Med Chem. 2014 Apr 10;57(7):3053-74.

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UAMC-1110 (UAMC1110, SP-13786, SP13786)

Biological Activity

Physicochemical Properties

References

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