UB-MBX-46

Chemical Structure : UB-MBX-46

Catalog No.: PC-25572Not For Human Use, Lab Use Only.

UB-MBX-46 is a potent, selective and allosteric antagonist of human P2X7 receptor (hP2X7R) antagonist with IC50 of 0.514 nM, 40.6 nM and 4.52 nM for human, rat and mouse P2X7R respectively.

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Biological Activity

UB-MBX-46 is a potent, selective and allosteric antagonist of human P2X7 receptor (hP2X7R) antagonist with IC50 of 0.514 nM, 40.6 nM and 4.52 nM for human, rat and mouse P2X7R respectively.

Physicochemical Properties

M.Wt	358.91
Formula	C21H27ClN2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	CC12C3(C)C(C2(C)C4)(C)CC4C(C3)(C(NNC5=C(Cl)C=CC=C5)=O)C1

References

1. Oken AC, et al. Nat Commun. 2025 Sep 15;16(1):8283.

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UB-MBX-46

Biological Activity

Physicochemical Properties

References

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