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UBASHIN-4

Chemical Structure : UBASHIN-4

CAS No.:

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UBASHIN-4 (LIT-13-108)

Catalog No.: PC-28292Not For Human Use, Lab Use Only.

UBASHIN-4 is a small-molecule inhibitor targeting UBASH3B 2HP domain, disrupts mitotic localization of UBASH3B and Aurora B, seletively induces arrest and cell death during mitosis without toxicity to normal cells, selectively suppresses breast and colon tumor growth in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UBASHIN-4 (LIT-13-108) is a small-molecule inhibitor targeting UBASH3B 2HP domain, disrupts mitotic localization of UBASH3B and Aurora B, seletively induces arrest and cell death during mitosis without toxicity to normal cells, selectively suppresses breast and colon tumor growth in vivo.

Physicochemical Properties

M.Wt 929.39
Formula C43H5sCF3N1107
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(4-((7R,10R)-10-benzyl-13-(4-chlorophenyl)-7-(3-guanidinopropyl)-3,6,9,12-tetraoxo-2,5,8,11-tetraazatridecyl)-1H-1,2,3-triazol-1-yl)ethyl)adamantane-1-carboxamide TFA salt

References

1. Pangou E, et al. EMBO Mol Med. 2026 Sep 22. doi: 10.1038/s44321-026-00519-0.

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