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Chemical Structure : UBCS385
Catalog No.: PC-21714Not For Human Use, Lab Use Only.
UBCS385 (Sirt4 inhibitor 60) is a potent, selective inhibitor of mitochondrial deacylase Sirtuin 4 (Sirt4) with IC50 of 0.9 uM.
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UBCS385 (Sirt4 inhibitor 60) is a potent, selective inhibitor of mitochondrial deacylase Sirtuin 4 (Sirt4) with IC50 of 0.9 uM.
UBCS385 displays weak effect on Sirt3 and high selectivity against Sirt1, −2, −5, and −6.
UBCS385 inhibits Sirt4 through binding to active site regions overlapping with the acyl-peptide binding regions but not with the NAD+ site.
| M.Wt | 586.05 | |
| Formula | C24H16ClN5O5S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martin Pannek, et al. J Med Chem. 2024 Jan 22. doi: 10.1021/acs.jmedchem.3c01496.
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