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UBMC-4

Chemical Structure : UBMC-4

CAS No.: 441287-99-6

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UBMC-4 (UBMC4)

Catalog No.: PC-47035Not For Human Use, Lab Use Only.

UBMC-4 is a potential Trypanosoma cruzi AKT-like pleckstrin homology (PH) domain, exhibits trypanocidal effect on T. cruzi amastigotes with EC50 of 1.85 uM (0.774 ug/mL).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UBMC-4 is a potential Trypanosoma cruzi AKT-like pleckstrin homology (PH) domain, exhibits trypanocidal effect on T. cruzi amastigotes with EC50 of 1.85 uM (0.774 ug/mL).
    UBMC-4 induces apoptosis-like markers in T. cruzi, reduced the tolerance to nutritional stress-triggered, apoptosis-like events, including DNA fragmentation, mitochondrial damage, and loss of plasma membrane integrity.
    UBMC-4 was well absorbed and reached plasma concentrations higher than the EC50, showing features that would aid in developing a new drug to treat Chagas disease.

    Physicochemical Properties

    M.Wt 418.514
    Formula C27H18N2OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-dibenzo-[b,d]-thien-2-yl-5-phenyl-1H-imidazol-2-yl)phenol

    References

    1. Bustamante C, et al. Pathogens. 2022 May 24;11(6):616.

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