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UC-764865

Chemical Structure : UC-764865

CAS No.: 2566480-63-3

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UC-764865 (UC764865)

Catalog No.: PC-72869Not For Human Use, Lab Use Only.

UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.
    UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.
    Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.

    Physicochemical Properties

    M.Wt 324.398
    Formula C18H16N2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-1-(4-methoxyphenyl)-3-((6-methyl-1H-benzo[d]imidazol-2-yl)thio)prop-2-en-1-one

    References

    1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695.

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