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Chemical Structure : UC-764865
Catalog No.: PC-72869Not For Human Use, Lab Use Only.
UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.
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UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.
UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.
Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.
| M.Wt | 324.398 | |
| Formula | C18H16N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695.
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