Chemical Structure : UCM-101
CAS No.:
UCM-101
(UCM101)
Catalog No.: PC-26192Not For Human Use, Lab Use Only.
UCM-101 is a potent, selective negative allosteric modulator of GluN2A-containing NMDA receptors with IC50 of 0.11 uM for GluN1/2A, 17-, 35-, and 118-fold selective for GluN1/2A over GluN1/2B, GluN1/2C, and GluN1/2D receptors, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UCM-101 is a potent, selective negative allosteric modulator of GluN2A-containing NMDA receptors with IC50 of 0.11 uM for GluN1/2A, 17-, 35-, and 118-fold selective for GluN1/2A over GluN1/2B, GluN1/2C, and GluN1/2D receptors, respectively.
UCM-101 inhibits NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in CA1 pyramidal neurons.
UCM-101 inhibits NMDA receptors by negatively modulating co-agonist binding to the GluN1 subunit via an allosteric mechanism that is conserved with previously described GluN2A-selective antagonists, TCN-201 and MPX-004.
Physicochemical Properties
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M.Wt
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404.59
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Formula
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C20H28N4OS2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-N-(cyclohexylmethyl)-2-((5-((1-phenylpropyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetamide
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References
1. Lotti JS, et al. J Gen Physiol. 2026 Jan 5;158(1):e202513872.
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