UCM-1306 (UCM1306) is a subtype-selective, non-covalent, orally bioavailable positive allosteric modulator of dopamine D1 receptor with EC50 of 60 nM.
UCM-1306 increases the dopamine maximal effect in a dose-dependent manner in human and mouse D1 receptors, is inactive in the absence of dopamine, does not display agonist activity.
UCM-1306 exhibits subtype selectivity over human D2, D3, D4, and D5 receptors.
UCM-1306 potentiates cocaine-induced locomotion and enhances l-DOPA recovery of decreased locomotor activity in reserpinized mice after oral administration.
