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Chemical Structure : UCM-1306
Catalog No.: PC-49303Not For Human Use, Lab Use Only.
UCM-1306 (UCM1306) is a subtype-selective, non-covalent, orally bioavailable positive allosteric modulator of dopamine D1 receptor with EC50 of 60 nM.
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UCM-1306 (UCM1306) is a subtype-selective, non-covalent, orally bioavailable positive allosteric modulator of dopamine D1 receptor with EC50 of 60 nM.
UCM-1306 increases the dopamine maximal effect in a dose-dependent manner in human and mouse D1 receptors, is inactive in the absence of dopamine, does not display agonist activity.
UCM-1306 exhibits subtype selectivity over human D2, D3, D4, and D5 receptors.
UCM-1306 potentiates cocaine-induced locomotion and enhances l-DOPA recovery of decreased locomotor activity in reserpinized mice after oral administration.
| M.Wt | 279.329 | |
| Formula | C14H14FNO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Javier García-Cárceles, et al. J Med Chem. 2022 Aug 31. doi: 10.1021/acs.jmedchem.2c00949.
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