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Chemical Structure : UCM-13369
Catalog No.: PC-22442Not For Human Use, Lab Use Only.
UCM-13369 is a small molecule inhibitor of nucleophosmin 1 (NPM1), inhibits NPM1 expression, downregulates the pathway associated with mutant NPM1 C+, inhibits tumorsphere growth of CSCs.
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UCM-13369 is a small molecule inhibitor of nucleophosmin 1 (NPM1), inhibits NPM1 expression, downregulates the pathway associated with mutant NPM1 C+, inhibits tumorsphere growth of CSCs.
UCM-13369 binds specifically to the C-end domain of the C+ mutant protein.
UCM-13369 inhibits gene and mutant NPM1 C+ protein expression and restores nucleolar localization.
UCM-13369 has efficacy against AML cell lines and primary cells.
UCM-13369 triggers apoptosis in AML cell lines and primary cells from AML patients and reduces tumor infiltration in a mouse model of AML with NPM1 C+ mutation.
UCM-13369 (50 mg/kg, tail vein injection) shows efficacy against AML cells in vivo.
| M.Wt | 389.54 | |
| Formula | C25H31N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sergio Algar, et al. JACS Au. 2024 Feb 9;4(5):1786-1800.
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