Chemical Structure : UCM-13369
CAS No.:
2921944-77-4
UCM-13369
(UCM13369)
Catalog No.: PC-22442Not For Human Use, Lab Use Only.
UCM-13369 is a small molecule inhibitor of nucleophosmin 1 (NPM1), inhibits NPM1 expression, downregulates the pathway associated with mutant NPM1 C+, inhibits tumorsphere growth of CSCs.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UCM-13369 is a small molecule inhibitor of nucleophosmin 1 (NPM1), inhibits NPM1 expression, downregulates the pathway associated with mutant NPM1 C+, inhibits tumorsphere growth of CSCs.
UCM-13369 binds specifically to the C-end domain of the C+ mutant protein.
UCM-13369 inhibits gene and mutant NPM1 C+ protein expression and restores nucleolar localization.
UCM-13369 has efficacy against AML cell lines and primary cells.
UCM-13369 triggers apoptosis in AML cell lines and primary cells from AML patients and reduces tumor infiltration in a mouse model of AML with NPM1 C+ mutation.
UCM-13369 (50 mg/kg, tail vein injection) shows efficacy against AML cells in vivo.
Physicochemical Properties
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M.Wt
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389.54
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Formula
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C25H31N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,3R,4R)-4-(2-((cyclopropylmethyl)amino)ethyl)-2-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-carbazol-3-amine
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References
1. Sergio Algar, et al. JACS Au. 2024 Feb 9;4(5):1786-1800.
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