Catalog No.: PC-26121Not For Human Use, Lab Use Only.
UCM-A86 is a selective positive allosteric modulator (PAM) of GluN1/GluN3 NMDA receptors with EC50 of 21 μM and 19 μM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively, selective over GluN1/GluN2A-D receptors.
UCM-A86 is a selective positive allosteric modulator (PAM) of GluN1/GluN3 NMDA receptors with EC50 of 21 μM and 19 μM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively, selective over GluN1/GluN2A-D receptors.
UCM-A86 selectively potentiates GluN1/GluN3A and GluN1/GluN3B receptors by 436% and 174%, respectively, relative to activation by glycine, with no activity at GluN1/GluN2A-D receptors.
UCM-A86 selectively potentiates responses from native GluN1/GluN3A receptors expressed in somatostatin-expressing interneurons of the somatosensory cortex with no modulation of hippocampal AMPA receptor-mediated and GluN1/2 NMDA receptor-mediated excitatory postsynaptic currents.
UCM-A86 demonstrates specific modulation of GluN3-containing NMDA receptors without affecting GluN2-containing NMDA receptors or AMPA receptors.
