Chemical Structure : UCM-A86
CAS No.:
1210899-51-6
UCM-A86
Catalog No.: PC-26121Not For Human Use, Lab Use Only.
UCM-A86 is a selective positive allosteric modulator (PAM) of GluN1/GluN3 NMDA receptors with EC50 of 21 μM and 19 μM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively, selective over GluN1/GluN2A-D receptors.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UCM-A86 is a selective positive allosteric modulator (PAM) of GluN1/GluN3 NMDA receptors with EC50 of 21 μM and 19 μM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively, selective over GluN1/GluN2A-D receptors.
UCM-A86 selectively potentiates GluN1/GluN3A and GluN1/GluN3B receptors by 436% and 174%, respectively, relative to activation by glycine, with no activity at GluN1/GluN2A-D receptors.
UCM-A86 selectively potentiates responses from native GluN1/GluN3A receptors expressed in somatostatin-expressing interneurons of the somatosensory cortex with no modulation of hippocampal AMPA receptor-mediated and GluN1/2 NMDA receptor-mediated excitatory postsynaptic currents.
UCM-A86 demonstrates specific modulation of GluN3-containing NMDA receptors without affecting GluN2-containing NMDA receptors or AMPA receptors.
Physicochemical Properties
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M.Wt
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338.35
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Formula
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C15H13F3N4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-((4-isopropylphenyl)thio)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine
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References
1. Benton AJ, et al. Mol Pharmacol. 2026 Jan 23;108(3):100103.
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