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Chemical Structure : UCM710
Catalog No.: PC-20128Not For Human Use, Lab Use Only.
UCM710 (Glycidyl Palmitoleate, UCM 710) is a potent, dual inhibitor of FAAH and ABHD6, inhibits both AEA and 2-AG hydrolysis in neuron homogenates with IC50 of 1.2 and 0.4 uM respectively, without significantly affecting MAGL activity.
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UCM710 (Glycidyl Palmitoleate, UCM 710) is a potent, dual inhibitor of FAAH and ABHD6, inhibits both AEA and 2-AG hydrolysis in neuron homogenates with IC50 of 1.2 and 0.4 uM respectively, without significantly affecting MAGL activity.
UCM710 dose-dependently inhibited AEA hydrolysis by FAAH and 2-AG hydrolysis by ABHD6 (IC50 = 4.0 and 2.4 μm, respectively) and had no effect on 2-AG hydrolysis by MAGL, also did not interact with CB1 and CB2 receptors.
UCM710 efficiently inhibited endocannabinoid (eCB) hydrolysis in neuron homogenates.
| M.Wt | 310.48 | |
| Formula | C19H34O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. William R Marrs, et al. J Biol Chem. 2011 Aug 19;286(33):28723-28728.
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