Catalog No.: PC-20128Not For Human Use, Lab Use Only.
UCM710 (Glycidyl Palmitoleate, UCM 710) is a potent, dual inhibitor of FAAH and ABHD6, inhibits both AEA and 2-AG hydrolysis in neuron homogenates with IC50 of 1.2 and 0.4 uM respectively, without significantly affecting MAGL activity.
UCM710 (Glycidyl Palmitoleate, UCM 710) is a potent, dual inhibitor of FAAH and ABHD6, inhibits both AEA and 2-AG hydrolysis in neuron homogenates with IC50 of 1.2 and 0.4 uM respectively, without significantly affecting MAGL activity.
UCM710 dose-dependently inhibited AEA hydrolysis by FAAH and 2-AG hydrolysis by ABHD6 (IC50 = 4.0 and 2.4 μm, respectively) and had no effect on 2-AG hydrolysis by MAGL, also did not interact with CB1 and CB2 receptors.
UCM710 efficiently inhibited endocannabinoid (eCB) hydrolysis in neuron homogenates.
Physicochemical Properties
M.Wt
310.48
Formula
C19H34O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
oxiran-2-ylmethyl (Z)-hexadec-9-enoate
References
1. William R Marrs, et al. J Biol Chem. 2011 Aug 19;286(33):28723-28728.
