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Chemical Structure : UCSF7447
Catalog No.: PC-38133Not For Human Use, Lab Use Only.
UCSF7447 (UCSF-7447, ZINC555417447) is a potent, selecive, brain permeable melatonin receptor MT-1 inverse agonist with Ki of 304 nM (hMT-1).
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UCSF7447 (UCSF-7447, ZINC555417447) is a potent, selecive, brain permeable melatonin receptor MT-1 inverse agonist with Ki of 304 nM (hMT-1); UCSF7447 increased basal cAMP with EC50 value of 41 nM at hMT1, selectivity for hMT1 over hMT2 of 53-fold, and hMT1 inverse agonist efficacies of 62%. UCSF7447 advanced the onset of activity by approximately 1 hour at 0.9 μg/mouse (about 0.03 mg/Kg), an effect similar to that of melatonin at its ED50 (0.72 μg/mouse). At a higher dose (30 μg/mouse, about 1 mg/Kg), UCSF7447 advanced the onset of running wheel activity with an amplitude similar to melatonin.
| M.Wt | 363.643 | |
| Formula | C15H12BrClN4 | |
| Appearance | Solid | |
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1. Reed M Stein, et al. Nature. 2020 Mar;579(7800):609-614.
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