Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : UCUF-965
Catalog No.: PC-21101Not For Human Use, Lab Use Only.
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment.
UCUF-965 is a partial agonist of CXCR4-mediated β-arrestin activity.
UCUF-965 is a potential allosteric activator of CXCR4/CXCL12 signaling.
UCUF-965 activates endogenous CXCR4 cell signaling in CEM-CCRF lymphoblasts, induces migration with EC50 of 0.4 uM, 10 µM UCUF-965 induces CXCR4-mediated calcium flux in comparison to 10 nM CXCL12 in CEM-CCRF cells.
UCUF-965 modulates wound healing specific miRNA levels in diabetic murine fibroblasts.
UCUF- 965 (10 uM) enhances diabetic wound healing in mouse model of wound healing.
| M.Wt | 405.52 | |
| Formula | C22H23N5OS | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Satyamaheshwar Peddibhotla, et al. Biochem Pharmacol. 2023 Aug 25;216:115764.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
