Catalog No.: PC-21101Not For Human Use, Lab Use Only.
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment.
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment.
UCUF-965 is a partial agonist of CXCR4-mediated β-arrestin activity.
UCUF-965 is a potential allosteric activator of CXCR4/CXCL12 signaling.
UCUF-965 activates endogenous CXCR4 cell signaling in CEM-CCRF lymphoblasts, induces migration with EC50 of 0.4 uM, 10 µM UCUF-965 induces CXCR4-mediated calcium flux in comparison to 10 nM CXCL12 in CEM-CCRF cells.
UCUF-965 modulates wound healing specific miRNA levels in diabetic murine fibroblasts.
UCUF- 965 (10 uM) enhances diabetic wound healing in mouse model of wound healing.
