Chemical Structure : UCUF-965
CAS No.:
2965316-77-0
UCUF-965
(UCUF965)
Catalog No.: PC-21101Not For Human Use, Lab Use Only.
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UCUF-965 (UCUF965) is a potent partial agonist and positive allosteric modulator of CXCR4 with EC50 of 0.02 uM, Emax=44% for CXCR4/CXCL12 signaling for β-arrestin-2 recruitment.
UCUF-965 is a partial agonist of CXCR4-mediated β-arrestin activity.
UCUF-965 is a potential allosteric activator of CXCR4/CXCL12 signaling.
UCUF-965 activates endogenous CXCR4 cell signaling in CEM-CCRF lymphoblasts, induces migration with EC50 of 0.4 uM, 10 µM UCUF-965 induces CXCR4-mediated calcium flux in comparison to 10 nM CXCL12 in CEM-CCRF cells.
UCUF-965 modulates wound healing specific miRNA levels in diabetic murine fibroblasts.
UCUF- 965 (10 uM) enhances diabetic wound healing in mouse model of wound healing.
Physicochemical Properties
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M.Wt
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405.52
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Formula
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C22H23N5OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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CCOC(C=CC=C1)=C1C2=NN=C3SCC(C4=CC=C(N5CCCC5)C=C4)=NN32
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References
1. Satyamaheshwar Peddibhotla, et al. Biochem Pharmacol. 2023 Aug 25;216:115764.
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