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Chemical Structure : UHC1
Catalog No.: PC-60334Not For Human Use, Lab Use Only.
UHC1 is a potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism.
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UHC1 is a potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism.
UHC1 binds directly to the LBD of PPARγ with IC50 of 800 nM, more potently blocks CDK5-mediated PPARγ phosphorylation at Ser-273 compared with SR-1664.
UHC1 effectively ameliorates the inflammatory response both in vitro and in high-fat diet-fed mice, dramatically improved insulin sensitivity without causing fluid retention and weight gain.
| M.Wt | 489.575 | |
| Formula | C31H27N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Choi SS, et al. J Biol Chem. 2014 Sep 19;289(38):26618-29.
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