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UHC1

Chemical Structure : UHC1

CAS No.: 1629960-95-7

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UHC1 (UHC-1;UHC 1)

Catalog No.: PC-60334Not For Human Use, Lab Use Only.

UHC1 is a potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UHC1 is a potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism.
    UHC1 binds directly to the LBD of PPARγ with IC50 of 800 nM, more potently blocks CDK5-mediated PPARγ phosphorylation at Ser-273 compared with SR-1664.
    UHC1 effectively ameliorates the inflammatory response both in vitro and in high-fat diet-fed mice, dramatically improved insulin sensitivity without causing fluid retention and weight gain.

    Physicochemical Properties

    M.Wt 489.575
    Formula C31H27N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4'-((2,3-dimethyl-5-((pyridin-3-ylmethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

    References

    1. Choi SS, et al. J Biol Chem. 2014 Sep 19;289(38):26618-29.

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