Catalog No.: PC-72248Not For Human Use, Lab Use Only.
UHRF1 inhibitor UM63 (UM63) is an anthraquinone compound that binds to the 5-methylcytosine (5mC) binding pocket of the SRA domain of UHRF1, inhibits the base-flipping process, which is crucial in the replication of DNA methylation profiles.
UHRF1 inhibitor UM63 (UM63) is an anthraquinone compound that binds to the 5-methylcytosine (5mC) binding pocket of the SRA domain of UHRF1, inhibits the base-flipping process, which is crucial in the replication of DNA methylation profiles.
UM63 impaired the UHRF1/DNMT1 interaction and decreased the overall methylation of DNA in treated cells.
Physicochemical Properties
M.Wt
239.23
Formula
C14H9NO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-amino-3-hydroxyanthracene-9,10-dione
References
1. Liliyana Zaayter, et al. Chemistry. 2019 Oct 17;25(58):13363-13375.
