UK5099 (PF-1005023) | MPC blocker | Probechem Biochemicals

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Chemical Structure : UK5099

CAS No.: 56396-35-1

UK5099 (PF-1005023, UK-5099)

Catalog No.: PC-38841Not For Human Use, Lab Use Only.

UK5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC), inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with IC50 of 50 nM.

Packing	Price	Stock
10 mg	$88	In stock
25 mg	$148	In stock
50 mg	$238	In stock
100 mg	$398	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UK5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC), inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with IC50 of 50 nM.
UK 5099 is a potent non-competitive inhibitor of pyruvate oxidation in castor-bean mitochondria.
UK 5099 impaired glucose tolerance in vivo.

Physicochemical Properties

M.Wt	288.3
Formula	C18H12N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

References

1. Parvin R, et al. J Biol Chem. 1978 Mar 25;253(6):1944-6.

2. Brailsford MA, et al. Biochem J. 1986 Oct 15;239(2):355-61.

3. Patterson JN, et al. J Biol Chem. 2014 May 9;289(19):13335-46.

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UK5099 (PF-1005023, UK-5099)

Biological Activity

Physicochemical Properties

References

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