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UMB-136

Chemical Structure : UMB-136

CAS No.: 2109805-83-4

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UMB-136 (UMB136;UMB 136)

Catalog No.: PC-60388Not For Human Use, Lab Use Only.

UMB-136 (UMB136) is a novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UMB-136 (UMB136) is a novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation.
    UMB-136 dramatically reversed HIV-1 latency at both low (2.5 uM) and high (5 uM) doses in multiple cell models of HIV-1 latency through promoting Tat-dependent transcriptional elongation and Tat-P-TEFb association.
    UMB-136 enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs.

    Physicochemical Properties

    M.Wt 417.513
    Formula C24H27N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-cyclohexyl-2-(4-(3,5-dimethylisoxazol-4-yl)-2-methoxyphenyl)imidazo[1,2-a]pyrazin-3-amine

    References

    1. Huang H, et al. Front Microbiol. 2017 Jun 7;8:1035.

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