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Chemical Structure : UMB-136
Catalog No.: PC-60388Not For Human Use, Lab Use Only.
UMB-136 (UMB136) is a novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation.
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UMB-136 (UMB136) is a novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation.
UMB-136 dramatically reversed HIV-1 latency at both low (2.5 uM) and high (5 uM) doses in multiple cell models of HIV-1 latency through promoting Tat-dependent transcriptional elongation and Tat-P-TEFb association.
UMB-136 enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs.
| M.Wt | 417.513 | |
| Formula | C24H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang H, et al. Front Microbiol. 2017 Jun 7;8:1035.
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