UMB-32 |CAS:1635437-39-6 Probechem Biochemicals

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Chemical Structure : UMB-32

UMB-32 (UMB 32;UMB32)

Catalog No.: PC-60389Not For Human Use, Lab Use Only.

UMB-32 is a potent, selective inhibitor of BRD4 with Kd of 550 nM, cellular IC50 of 724 nM.

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Biological Activity

UMB-32 is a potent, selective inhibitor of BRD4 with Kd of 550 nM, cellular IC50 of 724 nM.
UMB-32 also potently binds to the TAF1 (560 nM) and TAF1L (1.3 uM) bromodomains.
UMB-32 significantly induces HIV-1 reactivation.

Physicochemical Properties

M.Wt	361.4
Formula	C21H23N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1,1-dimethylethyl)-2-[4-(3,5-dimethyl-4-isoxazolyl)phenyl]-imidazo[1,2-a]pyrazin-3-amine

References

1. McKeown MR, et al. J Med Chem. 2014 Nov 13;57(21):9019-27.

2. Huang H, et al. Front Microbiol. 2017 Jun 7;8:1035.

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UMB-32 (UMB 32;UMB32)

Biological Activity

Physicochemical Properties

References

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