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UNC-CA2-103

Chemical Structure : UNC-CA2-103

CAS No.:

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UNC-CA2-103

Catalog No.: PC-22206Not For Human Use, Lab Use Only.

UNC-CA2-103 is a potent, selective tousled like kinase 2 (TLK2) inhibitor with enzyme IC50 of 18 nM, exhibit excellent selectivity over TLK1 (16% inhibition at 0.5 μM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UNC-CA2-103 is a potent, selective tousled like kinase 2 (TLK2) inhibitor with enzyme IC50 of 18 nM, exhibit excellent selectivity over TLK1 (16% inhibition at 0.5 μM).
    UNC-CA2-103 also exhibits overall kinome selectivity (S(10) = 0.027) accross DiscoverX kinome panel (>400 kinases).
    UNC-CA2-103 exhibits IC50 of 250 nM in ADP-Glo kinase activity assays.
    UNC-CA2-103 is a useful kinase chemical tool for elucidation of TLK2 biology.

    Physicochemical Properties

    M.Wt 344.37
    Formula C20H16N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[(3Z)-3-[(4-methyl-1H-imidazole-5-yl)methylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl]benzamide

    References

    1. Christopher R M Asquith, et al. Eur J Med Chem. 2024 Apr 2:271:116357.

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