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UNC2383

Chemical Structure : UNC2383

CAS No.: 2123481-48-9

UNC2383 (UNC-2383)

Catalog No.: PC-72947Not For Human Use, Lab Use Only.

UNC2383 (UNC-2383) is a small molecule that enhances the intracellular delivery and pharmacological effectiveness of antisense oligonucleotides (ONs) and splice switching oligonucleotides (SSOs).

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Biological Activity

UNC2383 (UNC-2383) is a small molecule that enhances the intracellular delivery and pharmacological effectiveness of antisense oligonucleotides (ONs) and splice switching oligonucleotides (SSOs).
UNC2383 is capable of boosting ON activity by inducing ON escape from late endosomes at concentrations of 5-30 uM to boost oligonucleotides (ONs) activity.

Physicochemical Properties

M.Wt 408.886
Formula C22H21ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-chloro-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)benzofuran-2-carboxamide

References

1. Jeremy P Bost, et al. Commun Biol. 2022 Mar 1;5(1):185.

2. B Yang, et al. Nucleic Acids Res. 2015 Feb 27;43(4):1987-96.

3. Ling Wang, et al. ACS Chem Biol. 2017 Aug 18;12(8):1999-2007.

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