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Chemical Structure : UNC2383
CAS No.: 2123481-48-9
Catalog No.: PC-72947Not For Human Use, Lab Use Only.
UNC2383 (UNC-2383) is a small molecule that enhances the intracellular delivery and pharmacological effectiveness of antisense oligonucleotides (ONs) and splice switching oligonucleotides (SSOs).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $198 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote |
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UNC2383 (UNC-2383) is a small molecule that enhances the intracellular delivery and pharmacological effectiveness of antisense oligonucleotides (ONs) and splice switching oligonucleotides (SSOs).
UNC2383 is capable of boosting ON activity by inducing ON escape from late endosomes at concentrations of 5-30 uM to boost oligonucleotides (ONs) activity.
| M.Wt | 408.886 | |
| Formula | C22H21ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-chloro-N-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)benzofuran-2-carboxamide |
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1. Jeremy P Bost, et al. Commun Biol. 2022 Mar 1;5(1):185.
2. B Yang, et al. Nucleic Acids Res. 2015 Feb 27;43(4):1987-96.
3. Ling Wang, et al. ACS Chem Biol. 2017 Aug 18;12(8):1999-2007.
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