UNC9750 | IPMK inhibitor | Probechem Biochemicals

Chemical Structure : UNC9750

UNC9750 (UNC 9750, UNC-9750)

Catalog No.: PC-22397Not For Human Use, Lab Use Only.

UNC9750 is a potent selective inhibitor of inositol phosphate multikinase (IPMK) with IC50 of 31.6 nM, inhibits human glioblastoma cell growth and selectively decreases cellular InsP5 abundance.

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Biological Activity

UNC9750 is a potent selective inhibitor of inositol phosphate multikinase (IPMK) with IC50 of 31.6 nM, inhibits human glioblastoma cell growth and selectively decreases cellular InsP5 abundance.
UNC9750 (10 µM, 48 hours) selectively and effectively inhibits InsP5 levels, without affecting InsP6 in human U251-MG glioblastoma cell.
UNC9750 displays excellent in vivo pharmacokinetics.

Physicochemical Properties

M.Wt	400.49
Formula	C23H24N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(1-cyclobutylpiperidin-4-yl)phenyl)-5-(1H-tetrazol-5-yl)benzo[c]isoxazole

References

1. Yubai Zhou, et al. bioRxiv [Preprint]. 2024 May 14:2024.05.09.593371.

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UNC9750 (UNC 9750, UNC-9750)

Biological Activity

Physicochemical Properties

References

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