Chemical Structure : UNI418
CAS No.:
1802068-51-4
UNI418
(UNI-418)
Catalog No.: PC-22798Not For Human Use, Lab Use Only.
UNI418 (UNI-418) is a potent, specific dual PIKfyve and PIP5K1C inhibitor with IC50 of 60.7 nM/60.1 nM for PIP5K1B/PIP5K1C, Kd of 0.78 nM for PIKfyve (100% inhibition at 1 uM), inhibits UNI418 inhibits SARS-CoV-2 infection of Vero cells with IC50 of 1.4 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UNI418 (UNI-418) is a potent, specific dual PIKfyve and PIP5K1C inhibitor with IC50 of 60.7 nM/60.1 nM for PIP5K1B/PIP5K1C, Kd of 0.78 nM for PIKfyve (100% inhibition at 1 uM), inhibits UNI418 inhibits SARS-CoV-2 infection of Vero cells with IC50 of 1.4 uM.
UNI418 inhibits autophagy, blocks autophagic flux by measuring the turnover rate of LC3-II in RPE1 cells, inhibits autophagosome-lysosome fusion and endolysosomal acidification.
UNI418 inhibits cathepsin maturation by preventing PIKfyve-dependent lysosomal trafficking, which is relevant to SARS-CoV-2 spike protein cleavage.
UNI418 efficiently inhibited SARS-CoV-2 replication in cells and reduced the production of progeny virus in culture supernatants.
UNI418 inhibits SARS-CoV-2 spike-mediated pseudovirus entry through PIP5K1C and PIKfyve.
Physicochemical Properties
|
M.Wt
|
364.41
|
|
Formula
|
C22H16N6
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)-4-quinazolinamine
|
References
1. Yuri Seo, et al. Exp Mol Med. 2024 Aug 1. doi: 10.1038/s12276-024-01283-2.
Contact Us
sales@probechem.com
