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Chemical Structure : UPGL00004
CAS No.: 1890169-95-5
Catalog No.: PC-35093Not For Human Use, Lab Use Only.
UPGL00004 (UPGL 00004) is a potent, allosteric inhibitor of glutaminase C (GAC) with IC50 of 29 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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UPGL00004 (UPGL 00004) is a potent, allosteric inhibitor of glutaminase C (GAC) with IC50 of 29 nM。
UPGL00004 inhibits breast cancer cell growth alone (MDA-MB-231) with IC50 of 70 nM, as well as tumor growth when combined with the anti-vascular endothelial growth factor antibody bevacizumab.
| M.Wt | 534.657 | |
| Formula | C25H26N8O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide |
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1. Huang Q, et al. J Biol Chem. 2018 Mar 9;293(10):3535-3545.
2. McDermott LA, et al. Bioorg Med Chem. 2016 Apr 15;24(8):1819-39.
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