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UR-144

Chemical Structure : UR-144

CAS No.: 1199943-44-6

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UR-144 (UR 144;UR144)

Catalog No.: PC-60762Not For Human Use, Lab Use Only.

UR-144 is a potent, selective full agonist of the peripheral cannabinoid receptor CB2 with Ki of 1.8 nM, >80-fold selectivity over CB1 (Ki=150 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    UR-144 is a potent, selective full agonist of the peripheral cannabinoid receptor CB2 with Ki of 1.8 nM, >80-fold selectivity over CB1 (Ki=150 nM).
    UR-144 possesses an EC50 of 421 nM for human CB1 receptors, and 72 nM for human CB2 receptors, produces bradycardia and hypothermia in rats at a dose of 10 mg/kg.

    Physicochemical Properties

    M.Wt 311.461
    Formula C21H29NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1-Pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

    References

    1. Banister SD, et al. ACS Chem Neurosci. 2015 Aug 19;6(8):1445-58.

    2. Dhopeshwarkar A, et al. J Pharmacol Exp Ther. 2016 Aug;358(2):342-51.

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