Chemical Structure : UR778Br
CAS No.:
866127-80-2
UR778Br
(UR 778Br)
Catalog No.: PC-22489Not For Human Use, Lab Use Only.
UR778Br is a potent small molecule inhibitor of scaffolding protein IQGAP1, taregting the IQGAP1-GRD domain, selectively inhibits growth of human acute myeloid leukemia.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
UR778Br is a potent small molecule inhibitor of scaffolding protein IQGAP1, taregting the IQGAP1-GRD domain, selectively inhibits growth of human acute myeloid leukemia.
UR778Br reduces proliferation, causes G2M cell cycle arrest, induces apoptosis and suppresses colony forming potential in leukemia cell lines.
UR778Br dose-dependently decreases viability, causs apoptosis and decreases colony formation potential in primary AML cells while sparing normal bone marrow cells.
IQGAP1 is a multi-domain, cytoskeletal protein, shown to be upregulated in many solid tumors.
Physicochemical Properties
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M.Wt
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418.29
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Formula
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C20H20BrNO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-bromo-1-butyl-3-hydroxy-3-(2-(2-hydroxyphenyl)-2-oxoethyl)indolin-2-one
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References
1. Sahasrabudhe DM, et al. Sci Rep. 2024 Jun 4;14(1):12868.
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