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URB447

Chemical Structure : URB447

CAS No.: 1132922-57-6

URB447 (URB-447)

Catalog No.: PC-20078Not For Human Use, Lab Use Only.

URB447 (URB-447) is a peripherally restricted CB(1) antagonist/CB(2) agonist with IC50 of 313 nM (rat CB1) and 41 nM (human CB2).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

URB447 (URB-447) is a peripherally restricted CB(1) antagonist/CB(2) agonist with IC50 of 313 nM (rat CB1) and 41 nM (human CB2).
URB447 inhibited GTPγS binding induced by the CB agonist WIN55,212-2 (1 μM) with EC50 of 4.9 uM in rat cerebellar membrane preparations.
URB447 (1 μM) inhibited cAMP accumulation induced by the β-adrenergic agonist isoproterenol (10 μM) in Hek-293 cells stably expressing mouse CB2 receptors.
URB447 (20 mg/kg, i.p.) drastically reduced total food consumption in male Swiss mice, did not alter motor activity.
URB447 (20 mg/kg, i.p.) selectively prevented peripherally mediated CB responses in mice.

Physicochemical Properties

M.Wt 400.91
Formula 25H21ClN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

[4-amino-1-(4-chlorobenzyl)-2-methyl-5-phenyl-1H-pyrrol-3-yl](phenyl)methanone

References

1. LoVerme J, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):639-43.

2. DiPatrizio NV, et al. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12904-8.

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