USP10-IN-3 |CAS:904448-58-4 Probechem Biochemicals

Chemical Structure : USP10-IN-3

USP10-IN-3

Catalog No.: PC-61934Not For Human Use, Lab Use Only.

USP10-IN-3 is a HBX19818 analog, potent and selective USP10 inhibitor, but does not inhibit USP7 (IC50>100 uM).

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Biological Activity

USP10-IN-3 is a HBX19818 analog, potent and selective USP10 inhibitor, but does not inhibit USP7 (IC50>100 uM).
USP10-IN-3 demonstrates specificity for FLT3- mutant MOLM13-luc+, MOLM14 and MV4,11 cell lines relative to the FLT3-null TF-1 cell line and to other leukemia lines not driven by FLT3.

Physicochemical Properties

M.Wt	401.979
Formula	C23H32ClN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9-chloro-N-(3-(dipropylamino)propyl)-5,6,7,8-tetrahydroacridine-3-carboxamide

References

1. Weisberg EL, et al. Nat Chem Biol. 2017 Dec;13(12):1207-1215.

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USP10-IN-3

Biological Activity

Physicochemical Properties

References

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